A new rapid differentiating solubility test for hemoglobin S.

B Warren; G Crosby; G L Evans

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PubMed · 1180257

A new rapid differentiating solubility test for hemoglobin S.

B Warren·G Crosby·G L Evans

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Abstract

A new test for sickling hemoglobin, SickleQuikTM, has been developed which has definitive advantages over existing turbidity tests. This test utilizes a biphasic liquid reagent system provided in individualized, ready-to-use reaction tubes which are stable at room temperature. The test differentiates homozygous from heterozygous S samples in less than eight minutes. Results are based on the color of a layer formed at the organic-aqueous interface and the color of the lower aqueous phase. Of more than 900 samples tested in independent laboratories, no false positive or false negative results occurred.

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Anemia, Sickle Cell Hemoglobin, Sickle Hemoglobins, Abnormal Heterozygote Homozygote Humans Methods Solubility Thalassemia Comparative Study Journal Article

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B Warren, G Crosby, G L Evans. 1975. A new rapid differentiating solubility test for hemoglobin S.. https://pubmed.ncbi.nlm.nih.gov/1180257/

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