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PubMed · 11804270

Beta2-adrenergic receptor genetics.

B A Raby·S T Weiss
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Abstract

The beta2-adrenergic receptor (beta2AR) is a positional candidate gene for asthma located on 5q31-33. There are 17 known polymorphisms in this gene. A determination of the functional significance of these polymorphisms is complicated by the lack of haplotypic assessment in most functional assays. The beta2AR gene is not an asthma-susceptibility gene but appears to be a minor determinant for lung function. The gene also has clear pharmacogenetic effects. Further work is needed to fully define the effects of haplotype on function, disease phenotype and pharmacogenetic effect.

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AnimalsHumansIn Vitro TechniquesPharmacogeneticsPolymorphism, Single NucleotideReceptors, Adrenergic, beta-2Journal ArticleReview

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B A Raby, S T Weiss. 2001. Beta2-adrenergic receptor genetics.. https://pubmed.ncbi.nlm.nih.gov/11804270/

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