Technology evaluation: T-cell activator, Xenova.

K L Knutson

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PubMed · 11804273

Technology evaluation: T-cell activator, Xenova.

K L Knutson

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Abstract

TA-HPV (therapeutic antigen-human papilloma virus) is a vaccine being developed by Xenova (formerly Cantab) for the potential treatment of cervical cancer. The antigen is intended to activate HPV-specific cytotoxic T-cells to attack tumor cells containing the viral antigen. Over 70% of patients with cervical cancer have tumor cells containing papillomavirus DNA [173070]. TA-HPV has reached phase IIa trials in 60 patients with high-grade anogenital intraepithelial neoplasia, including VIN3 (grade 3 vulvar intraepithelial neoplasia), to evaluate clinical efficacy [381386], [427159], [429895]. In addition, a phase II 'prime-boost' study of TA-HPV in combination with TA-CIN has been initiated at three centers across the UK [427159].

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Animals Clinical Trials as Topic Contraindications Female Lymphocyte Activation Mice Mice, Inbred C57BL Papillomavirus Infections T-Lymphocytes Tumor Virus Infections Uterine Cervical Neoplasms Viral Vaccines Evaluation Study Journal Article

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K L Knutson. 2001. Technology evaluation: T-cell activator, Xenova.. https://pubmed.ncbi.nlm.nih.gov/11804273/

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