A simple formula useful for positional cloning.

Richard T Durrett; Kai-Yi Chen; Steven D Tanksley

doi:10.1093/genetics/160.1.353

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A simple formula useful for positional cloning.

Richard T Durrett·Kai-Yi Chen·Steven D Tanksley

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Abstract

We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.

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Chromosome Mapping Cloning, Molecular Genetic Techniques Models, Genetic Models, Statistical Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Richard T Durrett, Kai-Yi Chen, Steven D Tanksley. 2002. A simple formula useful for positional cloning.. https://doi.org/10.1093/genetics%2F160.1.353

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