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PubMed · 11817025

Separation methods for camptothecin and related compounds.

L Zufía·A Aldaz·J Giráldez
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Abstract

This paper reviews working procedures for the analytical determination of camptothecin and analogues. We give an overview of aspects such as the chemistry, structure-activity relationships, stability and mechanism of action of these antitumor compounds. The main body of the review describes separation techniques. Sample treatment and factors influencing high-performance liquid chromatography development are delineated. Published high-performance liquid chromatographic methods are summarized to demonstrate the variability and versatility of separation techniques and a critical evaluation of separation efficiency, detection sensitivity and specificity of these methods is reported.

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Antineoplastic Agents, PhytogenicCamptothecinHumansStructure-Activity RelationshipJournal ArticleReview

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L Zufía, A Aldaz, J Giráldez. 2001-11-25. Separation methods for camptothecin and related compounds.. https://doi.org/10.1016/s0378-4347(01)00319-x

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