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Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds.

Y Hu·J O Hollinger·K G Marra
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Abstract

The controlled release of proteins in tissue-engineered implants is being examined with the potential application to improve vascularization and hasten tissue growth. Bovine serum albumin (BSA), was encapsulated within poly(D,L-lactic-co-glycolic acid) [PLGA] microparticles. The microparticles were coated with poly(vinyl alcohol) and incorporated into PLGA tissue-engineered scaffolds during fabrication. The release of BSA from PLGA microparticles, coated PLGA microparticles, and microparticles embedded in a porous PLGA scaffold was measured. We have developed a novel approach that will permit incorporation of coated polymeric microparticles during PLGA scaffold fabrication. Growth factors or drugs could be incorporated into the microparticles resulting in a long-term, controlled release.

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AnimalsCattleCoated Materials, BiocompatibleDelayed-Action PreparationsDrug CarriersDrug Delivery SystemsFluorescein-5-isothiocyanateLactic AcidMicroscopy, Electron, ScanningMicrospheresParticle SizePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolymersSerum Albumin, BovineTissue EngineeringJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Y Hu, J O Hollinger, K G Marra. 2001. Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds.. https://doi.org/10.3109/10611860108998777

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