Discovery in toxicology: mediation by gene expression array technology.

H K Hamadeh; P Bushel; R Paules; C A Afshari

doi:10.1002/jbt.10006

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Discovery in toxicology: mediation by gene expression array technology.

H K Hamadeh·P Bushel·R Paules·C A Afshari

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Abstract

Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new-age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and risk assessment processes will advance from the use of genomics techniques, which will lead to greater understanding of mechanism(s) of action of toxicants, development of novel biomarkers of exposure and effect, and better identification of sensitive subpopulations.

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Animals DNA, Complementary Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis Polymorphism, Genetic Risk Assessment Toxicology Journal Article Research Support, Non-U.S. Gov't Review

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H K Hamadeh, P Bushel, R Paules, C A Afshari. 2001. Discovery in toxicology: mediation by gene expression array technology.. https://doi.org/10.1002/jbt.10006

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