Potassium channel structures.

Senyon Choe

doi:10.1038/nrn727

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PubMed · 11836519

Potassium channel structures.

Senyon Choe

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Abstract

The molecular basis of K+ channel function is universally conserved. K+ channels allow K+ flux and are essential for the generation of electric current across excitable membranes. K+ channels are also the targets of various intracellular control mechanisms, such that the suboptimal regulation of channel function might be related to pathological conditions. Because of the fundamental role of K+ channels in controlling membrane excitability, a structural understanding of their function and regulation will provide a useful framework for understanding neuronal physiology. Many recent physiological and crystallographic studies have led to new insights into the workings of K+ channels.

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Animals Cell Membrane Humans Membrane Potentials Potassium Potassium Channels, Voltage-Gated Protein Structure, Tertiary Signal Transduction Synaptic Transmission Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Senyon Choe. 2002. Potassium channel structures.. https://doi.org/10.1038/nrn727

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