Multisubunit RNA polymerases.

Patrick Cramer

doi:10.1016/s0959-440x(02)00294-4

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Multisubunit RNA polymerases.

Patrick Cramer

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Abstract

Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.

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Animals Archaeal Proteins Binding Sites DNA DNA-Directed RNA Polymerases Eukaryotic Cells Humans Models, Molecular Protein Structure, Quaternary Protein Subunits RNA RNA Polymerase II Structure-Activity Relationship Transcription, Genetic Journal Article Review

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Patrick Cramer. 2002. Multisubunit RNA polymerases.. https://doi.org/10.1016/s0959-440x(02)00294-4

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