[Insulin secretion in rats after hypothalamic damage].

R S Gol'dberg; D E Finaeva; V F Dort-Gol'ts

PubMed · 118444

[Insulin secretion in rats after hypothalamic damage].

R S Gol'dberg·D E Finaeva·V F Dort-Gol'ts

Abstract

Experiments conducted on female Wistar rats showed that 24 hours after the injury of the ventromedial nuclei of the hypothalamus (VMNH) without animal starvation there occurred a slight reduction of insulin in the islets and a significant elevation of the blood immunoreactive insulin (IRI) level, without any glycemia reduction. In animals with intact VMNH glybenclamide produced no changes in the insulin depot in the pancreatic cells, but somewhat increased the IRI level. However, after the VMNH injury glybenclamide caused a sharp insulin depletion in the islets, and a marked elevation of IRI and a decrease of sugar in the blood.

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Animals Antigens Blood Glucose Female Glyburide Hypoglycemia Hypothalamus Insulin Insulin Antagonists Insulin Secretion Islets of Langerhans Paraventricular Hypothalamic Nucleus Rats Journal Article

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R S Gol'dberg, D E Finaeva, V F Dort-Gol'ts. [Insulin secretion in rats after hypothalamic damage].. https://pubmed.ncbi.nlm.nih.gov/118444/

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