New anti-malarial compounds from database searching.

Renate Griffith; Rachada Chanphen; Scott P Leach; Paul A Keller

doi:10.1016/s0960-894x(01)00811-3

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New anti-malarial compounds from database searching.

Renate Griffith·Rachada Chanphen·Scott P Leach·Paul A Keller

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Abstract

In a serendipitous result, pharmacophores generated for the database searching for new non-nucleoside inhibitors of the HIV-1 reverse transcriptase enzyme unearthed 12 new lead compounds which were active against the Plasmodium falciparum strain of malaria.

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Animals Antimalarials Databases, Factual HIV Reverse Transcriptase Heterocyclic Compounds Humans Inhibitory Concentration 50 Plasmodium falciparum Reverse Transcriptase Inhibitors Structure-Activity Relationship Journal Article

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Renate Griffith, Rachada Chanphen, Scott P Leach, Paul A Keller. 2002-02-25. New anti-malarial compounds from database searching.. https://doi.org/10.1016/s0960-894x(01)00811-3

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