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Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function.

Marc J Servant·Benjamin Tenoever·Rongtuan Lin
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Abstract

Recent molecular, biochemical, and gene disruption studies have demonstrated the essential role of interferon (IFN) regulatory factor-3, (IRF-3) and IRF-7 in the activation of type I IFN gene expression and the induction of the antiviral state. Both transcription factors share structural and functional properties, as well as a common mechanism of activation through C-terminal phosphorylation. The purpose of this review is to summarize recent investigations indicating that similar signalling pathways are likely involved in the activation of IRF-3 and IRF-7. Moreover, unique biochemical events, such as coactivator association and differential recognition of cis-acting elements, also illustrate the capacity of IRF-3 and IRF-7 to selectively regulate type I IFN and IFN-stimulated gene (ISG) expression.

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Amino Acid SequenceAnimalsDNA-Binding ProteinsHumansInterferon Regulatory Factor-3Interferon Regulatory Factor-7PhosphorylationProtein Structure, TertiaryResponse ElementsSignal TransductionTranscription FactorsTranscriptional ActivationVirusesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Marc J Servant, Benjamin Tenoever, Rongtuan Lin. 2002. Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function.. https://doi.org/10.1089/107999002753452656

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