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Structure and function of IRF-7.

Luwen Zhang·Joseph S Pagano
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Abstract

Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.

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Adaptor Proteins, Signal TransducingAmino Acid SequenceCarrier ProteinsChromosomes, Human, Pair 11Consensus SequenceCytoskeletal ProteinsDNA-Binding ProteinsHerpesvirus 4, HumanHumansInterferon Regulatory Factor-7Intracellular Signaling Peptides and ProteinsLIM Domain ProteinsPhosphorylationProtein Structure, TertiaryTranscription FactorsTranscriptional ActivationVirus LatencyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Luwen Zhang, Joseph S Pagano. 2002. Structure and function of IRF-7.. https://doi.org/10.1089/107999002753452700

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