PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 11851248

Penicillin sensitivity.

F E Palomeque·J Fulton·V J Derbes
View original source ↗Export metadata ↓

Abstract

The results obtained in this study indicate that there are various patterns of hypersensitivity to penicillin. In order to detect these variations it is suggested that two antigens, penicillin and penicilloyl-polylysine, be employed to test for both serum and skin sensitivity. Absolutely accurate predictions cannot be made from these tests, but it is felt that their use will minimize untoward reactions of the anaphylactic type in patients thus screened for penicillin allergy.

Explore related subjects

Drug HypersensitivityHumansIntradermal TestsPenicillinsSkin TestsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

F E Palomeque, J Fulton, V J Derbes. 1965. Penicillin sensitivity.. https://pubmed.ncbi.nlm.nih.gov/11851248/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2002

T cells in drug allergy.

In recent years, increasing evidence has indicated an important role for T cells in various drug-induced diseases. A detailed analysis of patients with various drug allergies revealed the existence of drug-specific T cells in the circulation or in eluate from skin infiltration in bullous, pustular, and maculopapular drug eruptions. The drug-specific T cells use the ab-T cell receptor CD4+ or CD8+ and react with drugs acting as haptens (covalently bound to larger molecules, such as penicillins), but also recognize drugs if they are bound only in a labile way to major histocompatibility complex molecules (noncovalent drug presentation). Functional analysis revealed a predominant IL-5 production by drug-specific CD4+ T cells in maculopapular exanthema (MPE) and bullous skin diseases, while patients with acute generalized exanthematous pustulosis have a peculiar T cell subset secreting high amounts of IL-8. Moreover, in MPE CD4+, perforin+ T cells were found in vitro and in immunohistology that had cytotoxic potential and killed keratinocytes in vitro and in vivo.

Drug Hypersensitivity↗