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Nuclear receptor coregulators: multiple modes of modification.

Ola Hermanson·Christopher K Glass·Michael G Rosenfeld
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Abstract

Many proteins have been characterized as coregulators that can be recruited by DNA-binding nuclear receptors to influence transcriptional regulation. Recent genetic and biochemical studies have shown that cellular levels of coregulators are crucial for nuclear receptor-mediated transcription, and many coregulators have been shown to be targets for diverse intracellular signaling pathways and post-translational modifications. This review focuses on the different modes of regulation of nuclear receptor coregulators and the implications for tissue- and context-specific transcriptional responses to hormone and membrane receptor signaling.

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AnimalsCell NucleusCytoplasmDNA-Binding ProteinsGene Expression RegulationHumansPhosphorylationReceptors, Cytoplasmic and NuclearTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Ola Hermanson, Christopher K Glass, Michael G Rosenfeld. 2002. Nuclear receptor coregulators: multiple modes of modification.. https://doi.org/10.1016/s1043-2760(01)00527-6

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