DNA polymerase beta.

Haitham T Idriss; Osama Al-Assar; Samuel H Wilson

doi:10.1016/s1357-2725(01)00131-5

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PubMed · 11854030

DNA polymerase beta.

Haitham T Idriss·Osama Al-Assar·Samuel H Wilson

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Abstract

Mammalian DNA polymerase beta(beta-pol) is a single polypeptide chain enzyme of 39kDa. beta-pol has enzymatic activities appropriate for roles in base excision repair and other DNA metabolism events involving gap-filling DNA synthesis. Many crystal structures of beta-pol complexed with dNTP and DNA substrates have been solved, and mouse fibroblast cell lines deleted in the beta-pol gene have been examined. These approaches have enhanced our understanding of structural and functional aspects of beta-pol's role in protecting genomic DNA.

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Amino Acid Sequence Animals Base Sequence DNA Polymerase beta DNA Repair DNA, Catalytic Exons Humans Lyases Models, Molecular Molecular Weight Protein Structure, Secondary Protein Structure, Tertiary Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Haitham T Idriss, Osama Al-Assar, Samuel H Wilson. 2002. DNA polymerase beta.. https://doi.org/10.1016/s1357-2725(01)00131-5

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