Rapid methods for bioavailability determination utilizing urinary excretion data.

P J Niebergall; E T Sugita; R L Schnaare

doi:10.1002/jps.2600641034

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PubMed · 1185547

Rapid methods for bioavailability determination utilizing urinary excretion data.

P J Niebergall·E T Sugita·R L Schnaare

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Abstract

Two equations were developed which enable urinary excretion data to be utilized for estimating drug bioavailability within 12 hr-starting between one and two half-lives of the drug, depending upon the relative rates of absorption, distribution, and elimination. Both equations were examined using simulated data for both the one- and two-compartment open models. One equation was tested using literature data with excellent results.

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Absorption Biological Availability Biopharmaceutics Fosfomycin Half-Life Methods Models, Biological Pharmaceutical Preparations Time Factors Journal Article

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P J Niebergall, E T Sugita, R L Schnaare. 1975. Rapid methods for bioavailability determination utilizing urinary excretion data.. https://doi.org/10.1002/jps.2600641034

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