Somatic immunoglobulin hypermutation.

Marilyn Diaz; Paolo Casali

doi:10.1016/s0952-7915(02)00327-8

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PubMed · 11869898

Somatic immunoglobulin hypermutation.

Marilyn Diaz·Paolo Casali

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Abstract

Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence. Recent evidence suggests a mechanism whereby DNA-breaks induce error-prone DNA synthesis in immunoglobulin V(D)J regions by error-prone DNA polymerases. The nature of the targeting mechanism and the trans-factors effecting such breaks and their repair remain to be determined.

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Animals B-Lymphocytes DNA Damage DNA-Directed DNA Polymerase Gene Expression Regulation, Developmental Gene Rearrangement, B-Lymphocyte Gene Rearrangement, T-Lymphocyte Humans Immunoglobulins Somatic Hypermutation, Immunoglobulin T-Lymphocytes Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Marilyn Diaz, Paolo Casali. 2002. Somatic immunoglobulin hypermutation.. https://doi.org/10.1016/s0952-7915(02)00327-8

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