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PubMed · 11869901

Gut intraepithelial lymphocyte development.

Delphine Guy-Grand·Pierre Vassalli
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Abstract

CD8alphabeta(+) and CD4(+) intraepithelial lymphocytes, the progeny of double-positive thymocytes, are oligoclonal T-cell populations that have accumulated in the gut wall as the result of repeated antigenic stimulations, which lead to rounds of traffic through the lymph/blood circuit ending in an alpha4beta7-integrin-driven homing all along the gut mucosa. In contrast, CD8alphaalpha(+) intraepithelial lymphocytes, which may be TCRgammadelta(+) or alphabeta(+), result in part from local differentiation in the gut, but studies comparing euthymic and athymic mice suggest a thymic double-negative origin for many of them.

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AnimalsCD8 AntigensCell LineageHumansImmunity, MucosalIntestinal MucosaPeyer's PatchesReceptors, Antigen, T-CellT-LymphocytesThoracic DuctJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Delphine Guy-Grand, Pierre Vassalli. 2002. Gut intraepithelial lymphocyte development.. https://doi.org/10.1016/s0952-7915(02)00330-8

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