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PubMed · 11869902

Novel approaches for identifying genes regulating lymphocyte development and function.

Adèle L Loy·Christopher C Goodnow
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Abstract

The draft sequence of the human and mouse genomes provides an unparalleled opportunity for understanding the genetic control of immune-cell development. Strategies can begin with a gene sequence and pursue a putative immune-system function by employing mRNA-expression profiling or creating gene knockouts in embryonic stem cells. The latter can be produced by utilising the Cre/Lox system, a tetracycline operon, a gene-trap method or chemical mutagenesis. Alternatively, mutant phenotypes (derived using the mutagen ethylnitrosourea) can be traced back to gene sequences.

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AnimalsCell DifferentiationCell LineageGene Expression Regulation, DevelopmentalGenomeHumansImmune SystemLymphocytesMiceJournal ArticleReview

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Adèle L Loy, Christopher C Goodnow. 2002. Novel approaches for identifying genes regulating lymphocyte development and function.. https://doi.org/10.1016/s0952-7915(02)00331-x

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