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PubMed · 11870866

Refining structural and functional predictions for secretasome components by comparative sequence analysis.

Arcady Mushegian
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Abstract

Comparative sequence analysis of presenilins reveals the conserved transmembrane domain shared with leukocyte antigen CD47, possibly involved in signal transduction. Sensitive techniques of multiple sequence alignment extend the earlier observation of the aminopeptidase homology domain in nicastrin to suggest that this protein may be a catalytically active component of secretasome involved in proteolysis or co-proteolysis of presenilin or beta-amyloid.

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Amino Acid SequenceAmyloid Precursor Protein SecretasesAntigens, CDCD47 AntigenCarrier ProteinsCatalytic DomainConserved SequenceForecastingHumansMembrane GlycoproteinsMembrane ProteinsMolecular Sequence DataPeptide HydrolasesPresenilin-1Protein ConformationProtein Structure, TertiarySequence AlignmentSequence Analysis, ProteinStructure-Activity RelationshipComparative StudyJournal Article

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Arcady Mushegian. 2002-04-01. Refining structural and functional predictions for secretasome components by comparative sequence analysis.. https://pubmed.ncbi.nlm.nih.gov/11870866/

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