Spatial and temporal pattern of Fgf-8 expression during chicken development.

Daniel Stolte; Ruijin Huang; Bodo Christ

doi:10.1007/s00429-002-0227-z

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Spatial and temporal pattern of Fgf-8 expression during chicken development.

Daniel Stolte·Ruijin Huang·Bodo Christ

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Abstract

This study analyzes the temporal and spatial expression pattern of Fgf-8 over a continuous series of developmental stages. Special emphasis is laid on the paraxial mesoderm where Fgf-8 expression is highly dynamic. Whereas the anterior portion of the unsegmented mesoderm is devoid of expression, Fgf-8 is upregulated in the posterior half of a newly formed somite. Soon after somite formation, this highly localized expression gives way to a more diffuse pattern of Fgf-8 expression at low levels in presumptive sclerotomal cells. During later somite maturation, transcripts become restricted to the myotome. Co-staining with the myotome marker MyoD reveals that Fgf-8 expression defines a subpopulation of muscle precursor cells.

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Animals Chick Embryo Embryonic and Fetal Development Fibroblast Growth Factor 8 Fibroblast Growth Factors Gene Expression Regulation, Developmental In Situ Hybridization Morphogenesis Neoplasm Proteins RNA, Messenger Somites Journal Article Research Support, Non-U.S. Gov't

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Daniel Stolte, Ruijin Huang, Bodo Christ. 2002. Spatial and temporal pattern of Fgf-8 expression during chicken development.. https://doi.org/10.1007/s00429-002-0227-z

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