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Essential immunoregulatory role for BCAP in B cell development and function.

Tetsuo Yamazaki·Kiyoshi Takeda·Kumiko Gotoh·Hiroshi Takeshima·Shizuo Akira·Tomohiro Kurosaki
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Abstract

BCAP was recently cloned as a binding molecule to phosphoinositide 3-kinase (PI3K). To investigate the role of BCAP, mutant mice deficient in BCAP were generated. While BCAP-deficient mice are viable, they have decreased numbers of mature B cells and B1 B cell deficiency. The mice produce lower titers of serum immunoglobulin (Ig)M and IgG3, and mount attenuated responses to T cell--independent type II antigen. Upon B cell receptor cross-linking, BCAP-deficient B cells exhibit reduced Ca(2+) mobilization and poor proliferative responses. These findings demonstrate that BCAP plays a pivotal immunoregulatory role in B cell development and humoral immune responses.

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Adaptor Proteins, Signal TransducingAnimalsAntibody FormationB-LymphocytesCalciumCarrier ProteinsIsoenzymesMiceMice, KnockoutPhosphatidylinositol 3-KinasesPhospholipase C gammaReceptors, Antigen, B-CellType C PhospholipasesJournal ArticleResearch Support, Non-U.S. Gov't

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Tetsuo Yamazaki, Kiyoshi Takeda, Kumiko Gotoh, Hiroshi Takeshima, Shizuo Akira, Tomohiro Kurosaki. 2002-03-04. Essential immunoregulatory role for BCAP in B cell development and function.. https://doi.org/10.1084/jem.20011751

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