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PubMed · 11883697

Technology evaluation: BL22, NCI.

Stefan Barth
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Abstract

BL22 (RFB4(dsFv)-PE38) is a recombinant Pseudomonas exotoxin-based immunotoxin under development by the National Cancer Institute for the treatment of B-cell malignancies. It is composed of the disulfide-stabilized Fv portion of the anti-CD22 antibody RFB4 genetically fused to a truncated form of Pseudomonas exotoxin A. It has entered phase I trials for the treatment of B-cell lymphoma.

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AnimalsAntibodiesClinical Trials as TopicEnterotoxinsHumansImmunotherapyImmunotoxinsLeukemia, B-CellLeukemia, Hairy CellLymphoma, B-CellMiceNeoplasmsPseudomonasJournal ArticleReview

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Stefan Barth. 2002. Technology evaluation: BL22, NCI.. https://pubmed.ncbi.nlm.nih.gov/11883697/

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