PubMed Health⌕ Search

PubMed · 11883770

Speech perception using maps based on neural response telemetry measures.

Abstract

OBJECTIVE: To determine how speech perception is affected for Nucleus cochlear implant users when their speech processor is programmed using neural response telemetry (NRT) measures rather than traditional behavioral estimates of threshold and maximum comfort level. DESIGN: Electrically evoked compound action potential (EAP) thresholds were measured for a group of 10 adult Nucleus cochlear implant users. These physiologic threshold estimates were used to create three SPEAK MAPs. One MAP ("+10/-20 MAP") was created using only the NRT data. The second MAP ("Combined MAP") was created using a combination of both EAP thresholds and a single behavioralmeasure of threshold and maximum comfort level from electrode 10. A third MAP ("Measured MAP") was created using standard programming techniques. Speech perception was then assessed using each of these three MAPs for either CUNY or HINT sentences presented at two different presentation levels (70 dB SPL and 55 dB SPL). RESULTS: On average, at the higher presentation level (70 dB SPL) subjects performed significantly better when using the Measured MAP than whenusing either of the NRT-based MAPs. No significant difference in speech perception was obtained for either of the three MAPs when the lower presentation level (55 dB SPL) was used. CONCLUSION: This study demonstrated that at relatively high presentation levels, speech perception scores obtained by subjects who use MAPs based solely or primarily on EAP thresholds ar eslightly lower than similar scores obtained using a more traditional MAP. This difference did not reach statistical significance at lower presentation levels. We interpret these findings in a positive light to suggest that although NRT-based MAPs may not be optimal, they are of sufficient quality to support reasonable levels of speech understanding. This is important to establish because these MAPs may prove to be most useful when very young children receive a cochlear implant.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Keely Seyle, Carolyn J Brown. 2002. Speech perception using maps based on neural response telemetry measures.. https://doi.org/10.1097/00003446-200202001-00009

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

A MAGIBU-based model for pediatric and juvenile CNS tumors: an in-house epigenetic decision-support framework compared with online DNA methylation classifiers.

Background: DNA methylation profiling is a tool that provides key support for central nervous system (CNS) tumor classification. However, diagnostically ambiguous pediatric cases may result in discordant outputs across classifiers. We developed MAGIBU, a cross-platform, projection-based framework that embeds individual methylomes into a fixed CNS reference landscape, ranking diagnostic entities by local epigenetic proximity to support clinician-led integrative diagnosis. Methods: As a proof-of-concept, we evaluated MAGIBU in eight morphologically challenging pediatric/juvenile CNS tumors with unresolved diagnoses after institutional and central pathology review. To establish a benchmark in the absence of a definitive histopathological ground truth, a consensus epigenetic reference was defined a priori for cases showing concordant results between the Heidelberg CNS Tumor Methylation Classifier and Methylscape Analysis. Comparisons were also performed with Epigenomic Digital Pathology (EpiDiP). To validate MAGIBU beyond this discovery cohort, performance was assessed at the family level across the CNS methylation spectrum (n = 678, 28 methylation families), on non-array platforms (whole-genome bisulfite sequencing and Oxford Nanopore), and in a focused analysis of the low-grade glioma and diffuse midline glioma compartment across four independent cohorts (n = 670). Results: In the discovery cohort, MAGIBU achieved high concordance with the consensus reference (Cohen's κ = 0.855), outperforming EpiDiP (κ = 0.278), which frequently placed low-grade tumors in proximity to higher-grade reference regions. Conclusions: MAGIBU provides a stable, quantitative differential diagnosis framework that mitigates the limitations of rigid categorical assignments. By leveraging a distance-based proximity metric, it offers a transparent decision-support tool that integrates effectively with clinical, radiological, and molecular data. While performance is inherently dependent on reference atlas composition, MAGIBU represents a robust complementary approach for the diagnostic workup of ambiguous CNS tumors.

Brain↗

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans.

Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders, including schizophrenia, autism and intellectual disability. Human carriers display a high prevalence of micro- and macrocephaly in deletion and duplication carriers, respectively. The underlying brain structural diversity remains largely unknown. We systematically called CNVs in 38 cohorts from the large-scale ENIGMA-CNV collaboration and the UK Biobank and identified 28 1q21.1 distal deletion and 22 duplication carriers and 37,088 non-carriers (48% male) derived from 15 distinct magnetic resonance imaging scanner sites. With standardized methods, we compared subcortical and cortical brain measures (all) and cognitive performance (UK Biobank only) between carrier groups also testing for mediation of brain structure on cognition. We identified positive dosage effects of copy number on intracranial volume (ICV) and total cortical surface area, with the largest effects in frontal and cingulate cortices, and negative dosage effects on caudate and hippocampal volumes. The carriers displayed distinct cognitive deficit profiles in cognitive tasks from the UK Biobank with intermediate decreases in duplication carriers and somewhat larger in deletion carriers-the latter potentially mediated by ICV or cortical surface area. These results shed light on pathobiological mechanisms of neurodevelopmental disorders, by demonstrating gene dose effect on specific brain structures and effect on cognitive function.

Brain↗

Time course of EEG background activity level before spontaneous awakening in the second semester of human life.

This research aimed at investigating the time course of the EEG background activity level before spontaneous awakening out of rapid eye movement (REM) sleep, and non-rapid eye movement sleep with and without slow wave sleep (NREMSWS+, NREMSWS-) in the second semester of life. Twelve infants from 25 to 54 weeks of life were continuously monitored by polygraphic recording and behavioural observation during the night, and the EEG activity was analyzed by a method of automatic analysis. The EEG activation level increased before the awakening out of NREMSWS+ sleep, and was always high both in REM sleep and in NREMSWS-.

Brain↗