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PubMed · 11890362

Eziopitant. Pfizer.

S Evangelista
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Abstract

Pfizer is developing ezlopitant, a neurokinin-1 antagonist, for the potential treatment of irritable bowel syndrome (IBS). The compound had undergone phase II trials in the US and Europe, and phase I in Japan for treatment of chemotherapy-induced emesis [290988], [320737], [329187]. A phase II, double-blind, randomized study was performed to assess the safety and efficacy of ezlopitant for the control of cisplatin-induced emesis. Treatment was well tolerated [290988]. Although the compound effectively controls emesis, it is less effective in controlling nausea, and development has been discontinued for the emesis indication [347367]. Ezlopitant has undergone a pilot study in 14 IBS patients [367631].

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AnimalsBenzylaminesBridged Bicyclo Compounds, HeterocyclicClinical Trials, Phase II as TopicColonic Diseases, FunctionalGastrointestinal AgentsHumansNeurokinin-1 Receptor AntagonistsStructure-Activity RelationshipJournal ArticleReview

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S Evangelista. 2001. Eziopitant. Pfizer.. https://pubmed.ncbi.nlm.nih.gov/11890362/

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