Studies on CD4 T cell immunity using somatic transgene immunization.

M Gerloni; M Zanetti

doi:10.3109/08830180109045581

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PubMed · 11890615

Studies on CD4 T cell immunity using somatic transgene immunization.

M Gerloni·M Zanetti

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Abstract

This review presents and discusses our recent data on the use of somatic transgene immunization in the induction of CD4 T cell responses in vivo. Somatic transgene immunization is a process that targets B lymphocytes resident in the spleen with DNA coding for antigenized immunoglobulin H chain genes. After transgenesis B lymphocytes function as antigen-producing and antigen-presenting cells. The studies reviewed herein describe the characteristics of the primary and memory CD4 response against a dominant Th cell determinant. In addition, they show how ad hoc modifications of the transgene result in the induction of a CD4 T cell response against Th cell determinants against which a response is normally not obtained. The new concept Th-Th cooperation is discussed.

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Amino Acid Sequence Animals B-Lymphocytes CD4-Positive T-Lymphocytes Genes, Immunoglobulin Immunization Immunoglobulin Heavy Chains Lymphocyte Cooperation Mice Mice, Transgenic Models, Immunological Oligopeptides Journal Article Research Support, U.S. Gov't, P.H.S.Review

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M Gerloni, M Zanetti. 2001. Studies on CD4 T cell immunity using somatic transgene immunization.. https://doi.org/10.3109/08830180109045581

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