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PubMed · 11892911

Oritavancin. Eli Lilly & Co.

J F Barrett
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Abstract

Oritavancin (LY-333328), a lead glycopeptide from a series targeted at vancomycin-resistant bacteria, especially enterococci, is under development by Eli Lilly for the potential treatment of bacterial infections. It entered phase III trials in the US in January 2001 [396223] and the company expects to submit an NDA by 2003 [396478]. Oritavancin has been reported to have activity comparable to that of vancomycin and teicoplanin (Aventis Pharma AG), but retains activity against glycopeptide-resistant bacterial strains [407519]. The bactericidal activity of oritavancin suggests that it may prove useful as a single agent therapy in the treatment of antibiotic-resistant enterococci. Although its mechanism of action is unclear, dimerization of the glycosyl portion stabilizing D-Ala-D-Ala binding has been suggested [337644].

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Anti-Bacterial AgentsBacteriaBacterial InfectionsClinical Trials, Phase I as TopicClinical Trials, Phase III as TopicGlycopeptidesHumansLipoglycopeptidesStructure-Activity RelationshipVancomycinJournal ArticleReview

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J F Barrett. 2001. Oritavancin. Eli Lilly & Co.. https://pubmed.ncbi.nlm.nih.gov/11892911/

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