Putting tumours in context.

M J Bissell; D Radisky

doi:10.1038/35094059

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PubMed · 11900251

Putting tumours in context.

M J Bissell·D Radisky

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Abstract

The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets.

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Animals Humans Matrix Metalloproteinases Neoplasms Stromal Cells Wound Healing Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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M J Bissell, D Radisky. 2001. Putting tumours in context.. https://doi.org/10.1038/35094059

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