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PubMed · 11904176

A tripeptide discriminator for stop codon recognition.

Yoshikazu Nakamura·Koichi Ito
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Abstract

Only recently has it been established that a tripeptide in the bacterial release factors (RFs), RF1 and RF2, is responsible for the stop codon recognition. This functional mimic of the anticodon of tRNA is referred to as a tripeptide 'anticodon' or a tripeptide discriminator. Here we review the experimental background and process leading to this discovery, and strengthen functional evidence for the tripeptide determinant for deciphering stop codons in mRNAs in prokaryotes.

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Codon, TerminatorPeptide Termination FactorsPeptidesProkaryotic CellsProtein BiosynthesisRNA, MessengerJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Yoshikazu Nakamura, Koichi Ito. 2002-03-06. A tripeptide discriminator for stop codon recognition.. https://doi.org/10.1016/s0014-5793(02)02330-x

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