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PubMed · 11906713

Phencyclidine increases vesicular dopamine uptake.

Michael J Crosby·Jarom E Hanson·Annette E Fleckenstein·Glen R Hanson
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Abstract

Phencyclidine (PCP) rapidly (within 1 h) increased vesicular dopamine uptake and binding of the vesicular monoamine transporter-2 (VMAT-2) ligand, dihydrotetrabenazine. Uptake returned to basal values 3 h in the striatum after a high-dose administration of this drug (15 mg/kg i.p.). In contrast, a similar pretreatment with another non-competitive NMDA receptor antagonist, dizocilpine;([5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine; MK-801; 1 mg/kg, i.p.), was without effect on vesicular dopamine uptake. Pretreatment with the dopamine D2 receptor antagonist, eticlopride, blocked the increase in vesicular dopamine uptake caused by PCP administration. These data demonstrate a heretofore unreported mechanism that may contribute to the ability of PCP to influence dopamine neuronal function and exert its pharmacological effects.

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AnimalsBinding, CompetitiveDizocilpine MaleateDopamineDopamine AntagonistsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsMalePhencyclidineRatsRats, Sprague-DawleySalicylamidesSynaptic VesiclesTetrabenazineTritiumComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Michael J Crosby, Jarom E Hanson, Annette E Fleckenstein, Glen R Hanson. 2002-03-01. Phencyclidine increases vesicular dopamine uptake.. https://doi.org/10.1016/s0014-2999(02)01298-0

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