PubMed · 11924970
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Royce W Murray. 2002-03-01. Controls and reliable conclusions.. https://doi.org/10.1021/ac021957i
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.