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PubMed · 11936555

Calcium and retinal function.

Abram Akopian·Paul Witkovsky
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Abstract

We survey the primary roles of calcium in retinal function, including photoreceptor transduction, transmitter release by different classes of retinal neuron, calcium-mediated regulation of gap-junctional conductance, activation of certain voltage-gated channels for K+ and Cl-, and modulation of postsynaptic potentials in retinal ganglion cells. We discuss three mechanisms for changing [Ca2+]i, which include flux through voltage-gated calcium channels, through ligand-gated channels, and by release from stores. The neuromodulatory pathways affecting each of these routes of entry are considered. The many neuromodulatory mechanisms in which calcium is a player are described and their effects upon retinal function discussed.

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AnimalsCalciumCalcium SignalingHumansRetinaJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Abram Akopian, Paul Witkovsky. 2002. Calcium and retinal function.. https://doi.org/10.1385/mn%3A25%3A2%3A113

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