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Bio-barcodes based on oligonucleotide-modified nanoparticles.

Jwa-Min Nam·So-Jung Park·Chad A Mirkin
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Abstract

By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 4(12) possible barcodes).

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Biosensing TechniquesDNAImmunoglobulin EImmunoglobulin GOligonucleotidesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Jwa-Min Nam, So-Jung Park, Chad A Mirkin. 2002-04-17. Bio-barcodes based on oligonucleotide-modified nanoparticles.. https://doi.org/10.1021/ja0178766

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