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PubMed · 11951792

[Radioactive stents: problems and potential solutions].

Christoph Hehrlein
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Abstract

BACKGROUND: The implantation of radioactive stents was the first procedure of a coronary brachytherapy in Europe examined in multicenter clinical trials. PROBLEMS OF RADIOACTIVE STENTS: After more than 400 patients with radioactive stents were analyzed, it became clear that overall restenosis rates were not reduced. A new phenomenon called the "edge effect" or "candy-wrapper" effect was discovered, which later was also described for catheter-based brachytherapy. Currently, the implantation of radioactive stents for the prevention of restenosis cannot be recommended. DRUG ELUTING STENTS: Although technical improvements of radioactive stents are theoretically possible, novel drug coated stents may overcome any future research of stent-based radiotherapy. Drug eluting stents induce antiproliferative effects beyond the stent margins. Edge effects were not observed in preliminary trials. However, long-term results need to be awaited.

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Angioplasty, Balloon, CoronaryAntibiotics, AntineoplasticBrachytherapyCoronary AngiographyCoronary RestenosisHumansImmunosuppressive AgentsPhosphorus RadioisotopesPilot ProjectsRandomized Controlled Trials as TopicSirolimusStainless SteelStentsEnglish AbstractJournal ArticleReview

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Christoph Hehrlein. 2002. [Radioactive stents: problems and potential solutions].. https://doi.org/10.1007/s15010-002-2338-0

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