Tungsten-containing enzymes.

N P L'vov; A N Nosikov; A N Antipov

doi:10.1023/a:1014461913945

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PubMed · 11952415

Tungsten-containing enzymes.

N P L'vov·A N Nosikov·A N Antipov

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Abstract

The biological importance of tungsten has been fully proved in the last decade due to isolation of a number of tungsten-containing enzymes (W-enzymes) from hyperthermophilic archaea. Tungsten was previously considered only as an antagonist of molybdenum, because the replacement of molybdenum by tungsten (due to their chemical similarity) leads to inactivation of molybdenum-containing enzymes (Mo-enzymes). In addition to the "true W-enzymes" in which tungsten cannot be replaced by molybdenum, recently some enzymes have been isolated which can use either molybdenum or tungsten in the catalytic process. This review briefly summarizes data on the participation of tungsten in catalysis by some enzymes and the structure of the active sites of W-enzymes.

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Bacteria Bacterial Proteins Binding Sites Enzymes Models, Molecular Molybdenum Tungsten Journal Article Research Support, Non-U.S. Gov't Review

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N P L'vov, A N Nosikov, A N Antipov. 2002. Tungsten-containing enzymes.. https://doi.org/10.1023/a%3A1014461913945

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