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Vasculitis due to gemcitabine.

A M C J Voorburg·F T van Beek·P H Th J Slee·C A Seldenrijk·F M N H Schramel
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Abstract

We report the first occurrence of gemcitabine-induced vasculitis. It concerns a 45-year-old man diagnosed with non-small lung cancer since 2 months. After the first cycle of chemotherapy, consisting of gemcitabine and cisplatin, he developed myalgia and swelling of arms and legs with impairment of movement. This re-occurred during the second cycle of chemotherapy. Further anemia, elevated ESR and increased creatininephosphokinase. A surgical biopsy showed leucocytoclastic vasculitis and necrosis of muscle tissue. The chemotherapy was stopped and the complaints disappeared and did not return.

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Antimetabolites, AntineoplasticCarcinoma, Non-Small-Cell LungDeoxycytidineHumansLung NeoplasmsMaleMiddle AgedMusclesMuscular DiseasesNecrosisTreatment OutcomeVasculitisGemcitabineCase ReportsJournal Article

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A M C J Voorburg, F T van Beek, P H Th J Slee, C A Seldenrijk, F M N H Schramel. 2002. Vasculitis due to gemcitabine.. https://doi.org/10.1016/s0169-5002(01)00464-0

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