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PubMed · 11969087

[Mobile gene cassettes and DNA integration elements ].

N P Kovalevskaia
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Abstract

Integrons are unique natural systems for capturing and spreading the antibiotic resistance genes among Gram-negative bacteria. Gene transfer into small genomes and into plasmids is via site-specific recombination. Integrons act as receptors of antibiotic resistance cassettes. There are known more than 50 cassettes conferring resistance to beta-lactams, aminoglycosides, trimethoprim, chloramphenicol, streptomycin, and other antibiotics. The structure of integrons and of gene cassettes are described and the mechanisms of capture, mobilization, and expression of cassettes considered.

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Anti-Bacterial AgentsDrug Resistance, MicrobialGene Expression Regulation, BacterialGram-Negative BacteriaOperonRecombination, GeneticEnglish AbstractJournal ArticleReview

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N P Kovalevskaia. [Mobile gene cassettes and DNA integration elements ].. https://pubmed.ncbi.nlm.nih.gov/11969087/

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