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Formation and function of the immunological synapse.

P Anton van der Merwe
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Abstract

Less than five years ago it was reported that cell surface molecules at the contact site between CD4 T cells and antigen-presenting cells redistribute into distinct patterns, forming an organized interface termed the immunological synapse. More recently, similar reorganized interfaces have been observed with CD8 T cells and NK cells, suggesting that they may be a common feature of lymphocyte activation. Although there has been some advance in our understanding of the mechanisms underlying this redistribution, its purpose remains unclear and controversial.

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AnimalsAntigen-Presenting CellsAntigens, CDCell PolarityHumansLeukosialinReceptors, Antigen, T-CellSialoglycoproteinsSynapsesT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P Anton van der Merwe. 2002. Formation and function of the immunological synapse.. https://doi.org/10.1016/s0952-7915(02)00350-3

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