A highly reactive titanium precatalyst for intramolecular hydroamination reactions.

Lutz Ackermann; Robert G Bergman

doi:10.1021/ol0256724

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A highly reactive titanium precatalyst for intramolecular hydroamination reactions.

Lutz Ackermann·Robert G Bergman

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Abstract

[reaction: see text]. Tetrakisamido titanium complexes are significantly more active than Cp2TiMe2 (1) in the intramolecular hydroamination of aminoalkynes and aminoallenes. In the latter case, the regioselectivity of the transformation depends on the nature of the precatalyst, yielding the most selective and reactive catalysis with the bis(sulfonamido) complex 11.

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Amination Amines Catalysis Cyclization Gas Chromatography-Mass Spectrometry Magnetic Resonance Spectroscopy Titanium Zirconium Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Lutz Ackermann, Robert G Bergman. 2002-05-02. A highly reactive titanium precatalyst for intramolecular hydroamination reactions.. https://doi.org/10.1021/ol0256724

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