Acetylcholine storage and its stabilization by morphine.

T Nogrady; J Dimaio

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PubMed · 1197924

Acetylcholine storage and its stabilization by morphine.

T Nogrady·J Dimaio

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Abstract

Acetylcholine binds to adenosine-triphosphate in vitro by ionic bonds between the ammonium ion and the phosphate, as shown by nuclear magnetic resonance data. This binding is further increased by morphine, which also binds to adenosine-triphosphate, but not to acetylcholine. The opiate antagonists naloxone and naltrexone show similar effects. This may offer a molecular explanation of acetylcholine release impairment in nerve endings by narcotic analgestic drugs.

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Acetylcholine Adenosine Triphosphate Animals Chemical Phenomena Chemistry In Vitro Techniques Kinetics Magnetic Resonance Spectroscopy Morphine Naloxone Naltrexone Sodium Chloride Spectrometry, Fluorescence Synaptosomes Journal Article

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T Nogrady, J Dimaio. 1975. Acetylcholine storage and its stabilization by morphine.. https://pubmed.ncbi.nlm.nih.gov/1197924/

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