A trypanocidal phenazine derived from beta-lapachone.

Cleverson Neves-Pinto; Valéria R S Malta; Maria do Carmo F R Pinto; Regina H A Santos; Solange L de Castro; Antônio Ventura Pinto

doi:10.1021/jm010377v

PubMed · 11985478

A trypanocidal phenazine derived from beta-lapachone.

Cleverson Neves-Pinto·Valéria R S Malta·Maria do Carmo F R Pinto·Regina H A Santos·Solange L de Castro·Antônio Ventura Pinto

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Abstract

An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi, and prophylaxis of blood in endemic areas. Our research comprises the synthesis and trypanocidal screening of derivatives from naphthoquinones. Herein a new phenazine, obtained from the reaction of beta-lapachone with aniline, has its structure established by physical data and X-ray analysis. It was 9 times more active against T. cruzi trypomastigotes than crystal violet.

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Aniline Compounds Animals Crystallography, X-Ray Phenazines Trypanocidal Agents Trypanosoma cruzi Journal Article Research Support, Non-U.S. Gov't

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Cleverson Neves-Pinto, Valéria R S Malta, Maria do Carmo F R Pinto, Regina H A Santos, Solange L de Castro, Antônio Ventura Pinto. 2002-05-09. A trypanocidal phenazine derived from beta-lapachone.. https://doi.org/10.1021/jm010377v

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