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Candidate-gene approaches for studying complex genetic traits: practical considerations.

Holly K Tabor·Neil J Risch·Richard M Myers
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Abstract

Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.

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AnimalsHumansLinkage DisequilibriumMolecular EpidemiologyMultifactorial InheritancePolymorphism, Single NucleotideReproducibility of ResultsResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.ReviewJournal Article

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Holly K Tabor, Neil J Risch, Richard M Myers. 2002. Candidate-gene approaches for studying complex genetic traits: practical considerations.. https://doi.org/10.1038/nrg796

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