The 3' 5' exonucleases.

Igor V Shevelev; Ulrich Hübscher

doi:10.1038/nrm804

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The 3' 5' exonucleases.

Igor V Shevelev·Ulrich Hübscher

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Abstract

Over the past few years, several new 3' 5' exonucleases have been identified. In vitro studies of these enzymes have uncovered much about their potential functions in vivo, and certain organisms with a defect in 3' 5' exonucleases have an increased susceptibility to cancer, especially under conditions of stress. Here, we look at not only the newly discovered enzymes, but also at the roles of other 3' 5' exonucleases in the quality control of DNA synthesis, where they act as proofreading exonucleases for DNA polymerases during DNA replication, repair and recombination.

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Amino Acid Sequence Animals DNA Helicases DNA Polymerase III DNA Repair DNA Replication Exodeoxyribonuclease V Exodeoxyribonucleases Humans Molecular Sequence Data Phosphoproteins Protein Structure, Tertiary RecQ Helicases Recombination, Genetic Sequence Alignment Werner Syndrome Helicase Journal Article Research Support, Non-U.S. Gov't Review

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Igor V Shevelev, Ulrich Hübscher. 2002. The 3' 5' exonucleases.. https://doi.org/10.1038/nrm804

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