Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils.

Y-K Kim; S-Y Oh; H-B Oh; S-Y Chun; S-H Cho; Y-Y Koh; K-U Min; Y-Y Kim

doi:10.1046/j.1365-2222.2002.01295.x

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Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils.

Y-K Kim·S-Y Oh·H-B Oh·S-Y Chun·S-H Cho·Y-Y Koh·K-U Min·Y-Y Kim

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Abstract

BACKGROUND: Our previous work on linkage analysis showed that histamine release from basophils to anti-IgE stimuli was linked to the gene marker of chromosome 11q13, where the beta chain of the high-affinity receptor for IgE (FcepsilonRI-beta) is located. OBJECTIVE: To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene. METHODS: Phenotypes of asthma, such as maximal histamine release from basophils and atopy, were measured from 80 randomly recruited asthmatic children. Polymorphisms of the FcepsilonRI-beta gene were determined by PCR-based methods. RESULTS: The polymorphism in exon 7, resulting in Glu to Gly substitution, was significantly associated with histamine release from basophils to anti-IgE stimuli, but not with total IgE levels and skin test responses to aeroallergens. CONCLUSION: This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils.

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Adolescent Alleles Asthma Basophils Calcimycin Child Female Histamine Release Humans Male Polymorphism, Single Nucleotide Random Allocation Receptors, IgE Journal Article Research Support, Non-U.S. Gov't

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Y-K Kim, S-Y Oh, H-B Oh, S-Y Chun, S-H Cho, Y-Y Koh, K-U Min, Y-Y Kim. 2002. Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils.. https://doi.org/10.1046/j.1365-2222.2002.01295.x

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