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PubMed · 11994445

A role for CD147 in thymic development.

Toufic Renno·Anne Wilson·Caroline Dunkel·Isabelle Coste·Karine Maisnier-Patin·Amélie Benoit de Coignac·Jean-Pierre Aubry·Rosemary K Lees·Jean-Yves Bonnefoy·H Robson MacDonald·Jean-François Gauchat
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Abstract

We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCRbeta selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.

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Amino Acid SequenceAnimalsAntibodies, MonoclonalAntigens, CDAntigens, NeoplasmAntigens, SurfaceAvian ProteinsBase SequenceBasiginBinding Sites, AntibodyBlood ProteinsCell CycleCell DifferentiationCell LineCloning, MolecularFemaleFetusHumansMembrane GlycoproteinsMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataOrgan Culture TechniquesReceptors, Antigen, T-Cell, alpha-betaThymus GlandTumor Cells, CulturedJournal Article

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Toufic Renno, Anne Wilson, Caroline Dunkel, Isabelle Coste, Karine Maisnier-Patin, Amélie Benoit de Coignac, Jean-Pierre Aubry, Rosemary K Lees, Jean-Yves Bonnefoy, H Robson MacDonald, Jean-François Gauchat. 2002-05-15. A role for CD147 in thymic development.. https://doi.org/10.4049/jimmunol.168.10.4946

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