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Truncated apoE forms tangle-like structures in a neuronal cell line.

M Cecilia Ljungberg·Rejith Dayanandan·Ayodeji Asuni·Tom H Rupniak·Brian H Anderton·Simon Lovestone
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Abstract

Apolipoprotein E is the predominant brain lipoprotein and polymorphic variation in the APOE gene the major genetic susceptibly factor for late onset Alzheimer's disease (AD). Recently it was reported that carboxyl-truncated ApoE fragments induce tangle-like structures in neurons. We confirm the finding: in mouse neuroblastoma cells truncated apoE fragments lacking the carboxyterminus induce structures that have the appearance of neurofibrillary tangles. However these tangles are not induced in non-neuronal cells even in the presence of co-expressed neurofilaments or tau. Further understanding of the basis of this cell specificity might add to understanding of the cell specificity of tangles in AD.

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Alzheimer DiseaseAnimalsApolipoproteins EBrainCHO CellsCOS CellsCricetinaeDNA, ComplementaryFetusImmunohistochemistryInclusion BodiesMiceNeurofibrillary TanglesNeurofilament ProteinsNeuronsPeptide FragmentsProtein Sorting SignalsProtein Structure, TertiaryTransport VesiclesTumor Cells, Culturedtau ProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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M Cecilia Ljungberg, Rejith Dayanandan, Ayodeji Asuni, Tom H Rupniak, Brian H Anderton, Simon Lovestone. 2002-05-07. Truncated apoE forms tangle-like structures in a neuronal cell line.. https://doi.org/10.1097/00001756-200205070-00026

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