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PubMed · 12010566

Genetic epidemiology: systemic sclerosis.

Ariane L Herrick·Jane Worthington
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Abstract

Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised phenotypically by fibrosis and ischaemic atrophy. Its aetiology is most likely multifactorial. A genetic predisposition to the condition is suggested by reports of familial SSc (a positive family history is the strongest risk factor yet identified), by animal models, and by disease-association studies, in which researchers have examined a wide variety of genes including those involved in fibrosis, in vascular function and structure, and in autoimmunity - the relative rarity of SSc has precluded linkage studies, except in the Choctaw Indians. Recent advances in genetic methodologies should further our understanding of this complex disease process.

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AnimalsAustraliaDisease Models, AnimalFemaleGenetic LinkageGenetic Predisposition to DiseaseHumansIndians, North AmericanMaleScleroderma, SystemicUnited StatesJournal ArticleReview

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Ariane L Herrick, Jane Worthington. 2002-01-16. Genetic epidemiology: systemic sclerosis.. https://doi.org/10.1186/ar402

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