Solid-phase synthesis of lipidated peptides.

Björn Ludolph; Frank Eisele; Herbert Waldmann

doi:10.1021/ja025768t

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Solid-phase synthesis of lipidated peptides.

Björn Ludolph·Frank Eisele·Herbert Waldmann

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Abstract

Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after appropriate deprotection of cysteine thiol groups as the key steps.

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Lipids Lipoproteins Peptides Journal Article Research Support, Non-U.S. Gov't

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Björn Ludolph, Frank Eisele, Herbert Waldmann. 2002-05-29. Solid-phase synthesis of lipidated peptides.. https://doi.org/10.1021/ja025768t

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