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New labdene iterpenes from Eupatorium glutinosum.

Hesham R El-Seedi·Noriko Sata·Kurt B G Torssell·Shigeru Nishiyama
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Abstract

The new diterpene glucoside 3,15-dihydroxy-ent-labd-7-en-17-oic acid 3-O-beta-D-glucoside (1) and its aglycone (2) have been isolated from Eupatorium glutinosum. The structures were determined by IR, one- and two-dimensional NMR, high-resolution mass spectrometry, chemical transformations, and comparison of spectroscopic data with closely related diterpenes. Crude extracts showed antimicrobial and cytotoxic activities, but compounds 1 and 2 showed only antimicrobial activity. These results support the vernacular medicinal use of the plant as an antimicrobial.

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Anti-Bacterial AgentsAntineoplastic Agents, PhytogenicAsteraceaeBacillus cereusChromatography, Thin LayerDiterpenesDrug Screening Assays, AntitumorEcuadorEscherichia coliGlucosidesHydrolysisMolecular ConformationMolecular StructurePlants, MedicinalPseudomonas aeruginosaStaphylococcus aureusTumor Cells, CulturedComparative StudyJournal Article

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Hesham R El-Seedi, Noriko Sata, Kurt B G Torssell, Shigeru Nishiyama. 2002. New labdene iterpenes from Eupatorium glutinosum.. https://doi.org/10.1021/np010595r

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